Dayo Omotoso
Divine Joseph
Comparative therapeutic role of ascorbic acid, α-tocopherol and riboflavin in mitigating hepatotoxicity induced by drugs and chemical toxins – a review
Dayo Omotoso
Divine Joseph
Department of Human Anatomy, Faculty of Basic Medical Sciences, Redeemer’s University, Ede, Nigeria
Department of Human Anatomy, Faculty of Basic Medical Sciences, Redeemer’s University, Ede, Nigeria
Received: 21 January 2025 / Revised: 10 March 2025 / Accepted: 16 March 2025 / Published: 30 September 2025
Abstract
Introduction and aim. The liver plays a central role in the metabolism of drugs, xenobiotics, and nutrients, making it highly susceptible to exposure to toxicity due to drugs and chemical toxins (DCT). DCT-induced hepatotoxicity (DIH), remains one of the most common causes of acute liver failure, and potential therapeutic agents such as ascorbic acid, α-tocopherol and riboflavin have been explored to mitigate DIH. This review summarizes the current knowledge in the experimental model.
Material and methods. This review was based in publications available on scientific databases such as PubMed, Scopus, Web of Science, and Google Scholar. After the abstract evaluation, the relevant articles were selected for further analysis.
Analysis of the literature. The vital role of oxidative stress and inflammation in mediating DIH has been demonstrated. Hence, the most effective therapeutic intervention includes agents that exhibit potent antioxidant and anti-inflammatory properties such as ascorbic acid, α-tocopherol and riboflavin.
Conclusion. The comparative therapeutic role of ascorbic acid, α-tocopherol and riboflavin against DIH involves the reparation of hepatic histomorphological impairments and modulation of biochemical and molecular alterations that characterized the onset and progression of DIH.
Cite
Omotoso D, Joseph D. Comparative therapeutic role of ascorbic acid, α-tocopherol and riboflavin in mitigating hepatotoxicity induced by drugs and chemical toxins – a review. Eur J Clin Exp Med. 2025;23(3):742–749. doi: 10.15584/ejcem.2025.3.4.
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