Clinical profile and management of patients with pediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2 – single-center experience

Paulina Opalińska-Zielonka
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Katarzyna Wiącek
Paweł Marczak
Krystyna Piasecka
Bartosz Korczowski
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Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland
Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland
Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland
Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland
Department of Pediatrics and Pediatric Gastroenterology, College of Medical Sciences, University of Rzeszów, Rzeszów, Poland
Received: 10 October 2021 / Revised: 9 December 2021 / Accepted: 11 December 2021 / Published: 30 March 2022

Abstract

Introduction and aim. Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) is a new condition that has emerged in children during the COVID-19 pandemic. Many clinical signs and symptoms resemble those found in Kawasaki disease (KD).

Material and methods. The following data were considered: clinical presentation, comorbidities, laboratory findings, abnormalities in additional tests, exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the child and his family members, applied treatment and return to full health.

Results. In the presented study nineteen children were analyzed. Fever was a universal finding in our group and it’s mean duration was 7 days (range 5-9). Other common symptoms included abdominal pain and severe weakness (in 89.5%), rash and conjunctivitis (in 84.2%), vomiting (in 73.7%) and mucous membrane involvement (in 63.2%). In nearly half of cases, echocardiography revealed fluid in the pericardial sac and left ventricular systolic dysfunction (in 52.6% and 47.4% respectively). 21.1% of patients had coronary artery abnormalities. 26,3% of the children required treatment with dopamine and/or milrinone. In 15.7% ICU admissions and assisted ventilation was necessary. No deaths were recorded.

Conclusion. One should bear in mind that PIMS-TS can mimic KD, appendicitis and meningitis, which may pose a diagnostic challenge.

 

Cite

Opalińska-Zielonka P, Wiącek K, Marczak P, Piasecka K, Korczowski B. Clinical profile and management of patients with pediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2 – single-center experience. Eur J Clin Exp Med. 2022;20(1):11–17. doi: 10.15584/ejcem.2022.1.2

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