Abbas Mosad Ajeed
ID
Nabaa Hassan Naif
ID
Aliaa Hashim Farag
ID
Osama A. Mohsein
ID
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Al-Kunooze University College, Faculty of Pharmacy, Basra, Iraq
Department of Biochemistry, Faculty of Medicine, University of Kerbala, Kerbala, Iraq
Basic Sciences, Dentistry College, Uruk Private University, Baghdad, Iraq
Department of Medical Laboratory Techniques, Mazaya University College, Thi-Qar, Iraq
Received: 6 December 2024 / Revised: 10 December 2024 / Accepted: 13 December 2024 / Published: 30 June 2025

Abstract

Introduction and aim. Sleeve gastrectomy has become one of the most common surgical procedures in the world recently, due to its role in promoting weight loss and reducing the risk of obesity-related diseases. This study aims to determine the levels of inflammatory and nutritional factors in patients undergoing gastric sleeve surgery.


Material and methods. A case-control study was conducted including 150 patients who underwent gastric sleeve surgery and 50 healthy participants as a control group. Inclusion criteria included patients aged 45–65 years with a BMI ≥35 kg/m². Levels of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), adiponectin, interferon-gamma, IL-10, IL-1β, monocyte chemoattractant protein-1, fasting blood glucose (FBG), serum amyloid A, iron, ferritin, calcium, and vitamin D3 were measured using enzyme-linked immunosorbent assay.


Results. The study revealed that the control group (22.8±3.6 kg/m²) had a significantly reduced BMI compared to the patients who underwent sleeve gastrectomy (35.5±7.1 kg/m², (p<0.001). Elevated levels of C-reactive protein, IL-6, TNF-α, and FBG were seen in the postoperative group, although adiponectin levels were dramatically reduced (p<0.001). Furthermore, the postoperative patients manifested significantly reduced levels of iron, calcium, and vitamin D3, suggesting a profound insufficiency in these vital nutrients and their possible consequences on their long-term well-being.


Conclusion. The study results indicate that patients who underwent gastric sleeve surgery had significantly lower levels of iron, ferritin, calcium, and vitamin D3, compared to the control group. This is due to the effect of surgery on the absorption of nutrients, which causes a deficiency in vitamins and minerals necessary for bone and body health.

 

Cite 

Ajeed AM, Naif NH, Farag AH, Mohsein OA. Assessing the impact of sleeve gastrectomy on micronutrient levels and inflammatory markers – a case-control study. Eur J Clin Exp Med. 2025;23(2):369–377. doi: 10.15584/ejcem.2025.2.13.

 

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