A brief review of the cardiovascular complication of COVID-19 what is the pathophysiology of arrhythmia during infection?
Abstract
Introduction and aim. COVID-19, caused by SARS-CoV-2, significantly affects the cardiovascular system beyond its respiratory manifestations. This review examines the intricate relationship between COVID-19 and cardiovascular complications, focusing on cardiac arrhythmias and their underlying pathophysiology.
Material and methods. A comprehensive literature search was conducted in PubMed and Google Scholar from its inception to December 2024, including peer-reviewed articles published in English.
Analysis of literature. In COVID-19, a spectrum of cardiovascular complications is observed, including acute myocardial infarction, arrhythmias, myocarditis, venous thromboembolism, and heart failure/cardiac shock. The pathophysiology of cardiovascular damage in COVID-19 involves multiple mechanisms, primarily including direct viral cardiotoxicity, systemic inflammation, and hypercoagulability. Arrhythmias are a common cardiac complication in COVID-19, encompassing a range of disturbances, from bradycardia to ventricular fibrillation. The mechanisms underlying arrhythmias in COVID-19 are multifaceted, including direct viral injury to cardiomyocytes, hypoxia, systemic inflammation, hyperthermia, autonomic imbalance, electrolyte imbalances, side effects of medications, and drug-drug interactions.
Conclusion. Understanding the complex interplay of these factors is crucial for the early diagnosis and appropriate management of cardiac complications in patients with COVID-19. To mitigate cardiovascular morbidity and mortality in individuals with COVID-19, cardiovascular monitoring and the development of targeted therapeutic strategies are highly recommended.
Cite
Djallalluddin D, Utomo AK, Wanahari TA. A brief review of the cardiovascular complication of COVID-19 what is the pathophysiology of arrhythmia during infection? Eur J Clin Exp Med. 2025;23(3):731–741. doi: 10.15584/ejcem.2025.3.1.

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