Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes

Purti Mishra
ID
Pooja Sethi
ID
Email src
Selva Kumar Ramasamy
ID
Adesh K. Saini
ID
Hardeep Singh Tuli
ID
Divya Mittal
ID
Aarti Trehan
Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Faculty of Agriculture, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Department of Chemistry, Arya Kanya Mahavidyalya, Shahabad Markanda, Haryana, India
Received: 13 October 2023 / Revised: 17 December 2023 / Accepted: 28 December 2023 / Published: 30 March 2024

Abstract

Introduction and aim. At present, several microbial diseases are prominent and of concern worldwide. The intent of this study was to examine the antibacterial potential of newly synthesized tetradentate macrocyclic complexes against different bacte rial strains. The macrocyclic scaffold has gained attention as a biologically active class of supramolecular chemistry due to its unique properties and ability to target various microorganisms. Thus, the goal of the present study was to develop a series of biologically active transition metal-based macrocycles.

Material and methods. All macrocyclic compounds were synthesized by a template method and validated by molar conductiv ity, elemental studies, and spectral and magnetic studies. Antibacterial activities of all metal complexes were evaluated against Escherichia coli (MTCC 739) and Staphylococcus aureus (MTCC 731) bacterial strains by taking ampicillin as a standard reference drug. DNA photocleavage potential was explored using agarose gel electrophoresis.

Results. Results revealed the formation of novel macrocyclic complexes via tetra nitrogen bond trapping of metals. Copper complexes have strong potential against S. aureus bacteria as copper and nickel both show good DNA photocleavage potential.

Conclusion. The findings endorse the biomedical relevance of these macrocyclic scaffolds, suggesting avenues for further exploration in targeted drug delivery and potential clinical applications. The proposed octahedral geometry for the complexes enhances our understanding of their structural aspects. This research contributes substantively to the field, laying the foundation for future investigations in advanced antimicrobial design and application.

 

Cite

Mishra P, Sethi P, Ramasamy SK, Saini AK, Tuli HS, Mittal D, Trehan A. Antibacterial, DNA photocleavage and molecular dock ing studies of newly prepared Schiff-based macrocyclic complexes. Eur J Clin Exp Med. 2024;22(1):154–163. doi: 10.15584/ ejcem.2024.1.27.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited